Birmingham stabbings: Manhunt as one killed and seven hurt
The first stabbing was in Constitution Hill at 00:30 BST then the killer moved south, apparently attacking at random, officers said.
The stabbings did not appear terrorism related, gang related or connected to disorder, West Midlands Police said.
Murder inquiry detectives said they were hunting a single suspect.
The force urged anyone with CCTV or mobile footage to contact them.
One man died, another man and a woman suffered critical injuries and five other people were left with non-life-threatening injuries.
Ch Supt Steve Graham said the attacker went on to stab people in Livery Street, Irving Street and finally in Hurst Street, where the city's Gay Village meets the Chinese Quarter, at about 02:20 BST.
Police said there was no evidence the stabbings were a hate crime.
Mr Graham said officers - some armed - remained across the city centre to reassure people.
He added they had received a number of descriptions of the suspect but would not be releasing any details at this time.
Mr Graham said: "The events during the early hours of this morning are tragic, shocking and understandably frightening.
"It does appear to be a random attack because we haven't found any links between the victims, either in their nature or in where they were socialising.
"Please be assured that we are doing absolutely everything we can to find whoever was responsible and try to understand what exactly happened."
Savvas Sfrantzis, who was working nearby, said he saw a man stab a girl multiple times but people thought at first he was trying to take her necklace.
"He was like very cold and he wasn't panicking and he wasn't reacting or anything. After he stabbed her between five and seven times... he walked off as if nothing has happened," he said.
Officers earlier found a knife in a drain but Mr Graham said it was "way too early" to say if it was connected to the case.
"What I think it does suggest is the comprehensive nature of our inquiry - that already we've got people going down drains - we've got that level of detailed searches taking place," he said.
David Nash, who was running the Village Inn in Hurst Street, said after a "normal night" he heard someone shout "stop him - he's just stabbed somebody" between 02:00 and 02:15.
"The bars were starting to wind down and the next thing we know the area is engulfed with armed response vehicles, normal police vehicles, police on foot, ambulances," he said.
"They just came from absolutely nowhere and the area was full of them and then the police helicopter was up."
He said he then saw paramedics treating two people who seemed to have been stabbed.
Nathan Hudson, from West Midlands Ambulance Service, said 14 ambulances attended and he was among 11 paramedic officers who were also sent to help.
Prime Minister Boris Johnson thanked emergency services "working hard at the scene".
He tweeted: "All my thoughts are with those affected by the terrible incident in Birmingham last night."
Witness Cara Curran, a club promoter working in the Arcadian Centre, said it had been busier during the evening than it had been at any time since the start of lockdown.
She said she had finished her shift at about 00:30 BST and was drinking with colleagues when she heard a "loud bang and quite a lot of commotion".
The streets in the area had already been closed to traffic due to coronavirus restrictions.
Outside the cordoned-off area, much of the city centre, such as Birmingham's Bullring shopping centre and the Sealife Centre in Brindleyplace, is open as usual.
The West Midlands Police and Crime Commissioner (PCC) David Jamieson said police would be working with the city council to see if there were "any further measures that need to be taken in the city centre", following the stabbings.
A rise in violence was "almost inevitable" due to the pandemic, when people were suffering "pent-up feelings" and some were unsure of their futures, the Labour PCC said.
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